Under the skin of your stomach or thigh, and in some cases the upper arm. The exact rule depends on your medication and device, so each one is set out below as its own manufacturer gives it: the Wegovy pen, the Zepbound KwikPen, the Zepbound single-dose vial and the Repatha SureClick autoinjector. Always follow the instructions for use that came with your medication.
Wegovy pen
Wegovy is injected under the skin (subcutaneously) of your stomach (abdomen), thigh or upper arm. Do not inject it into a muscle or a vein.
Stomach: use your lower stomach and keep 2 inches away from your belly button.
Thigh: use your upper leg (the front of the thigh).
Upper arm: make sure you can clearly see the pen window while injecting.
Do not inject into an area where the skin is tender, bruised, red or hard, and avoid areas with scars or stretch marks.
Change (rotate) your injection site with each injection. You may inject into the same body area each week, but not in the exact same spot each time.
Zepbound KwikPen
You or another person can inject the medicine in your thigh or stomach (abdomen), at least 2 inches from the belly button. Another person should give you the injection in the back of your upper arm. Do not inject Zepbound into a muscle or a vein.
Change (rotate) your injection site each week. You may use the same area of your body, but choose a different injection site in that area.
Zepbound single-dose vial
You can inject Zepbound under the skin (subcutaneously) of your stomach area (abdomen) or thighs. Someone else can inject in your stomach area, thighs or the back of the upper arms. Do not inject Zepbound into a muscle or a vein.
Change (rotate) your injection site within the area you choose for each dose. This reduces your risk of lipodystrophy (pits in the skin or thickened skin) and localized cutaneous amyloidosis (skin with lumps) at the injection sites.
Do not inject where the skin has pits, is thickened or has lumps. Do not inject where the skin is tender, bruised, scaly or hard, or into scars or damaged skin. Do not inject Zepbound in the same injection site you use for other medicines.
Repatha SureClick autoinjector
Use the thigh or the stomach, except for 2 inches around the belly button. Someone else can inject in your thigh, stomach or the back of your upper arm.
Change the injection site each time, shifting the area of the injection to avoid skin irritation. Avoid areas with scars or stretch marks, or where the skin is tender, bruised, red, hard or raised, or has a thick or scaly patch or a lesion.
If your device looks different from the one described here, follow the instructions for use in its carton, and message your clinician if you’re unsure.
Who to contact
For anything about which area to use, how your skin reacts where you inject, how you feel on your medication, or a missed dose, message your clinician through the chat on your Dashboard. Reply to the most recent message about your prescription.
For a damaged pen, vial, or device, or a replacement, contact your pharmacy.
In an emergency, call 911. If you’re having thoughts of harming yourself, call or text 988.
Sources
This article follows the manufacturers’ instructions for Wegovy, Zepbound and Repatha. If you’d like to read them yourself:
Wegovy Medication Guide, Novo Nordisk, on DailyMed (the FDA’s label library), revised June 2026
How to use the Wegovy pen, Novo Nordisk, updated June 2026
Zepbound KwikPen Instructions for Use, Eli Lilly and Company, revised January 2026
Zepbound single-dose vial Instructions for Use, Eli Lilly and Company, revised April 2026
Repatha SureClick autoinjector Instructions for Use, Amgen, revised August 2025 (the instructions are inside the full Repatha labeling PDF, after the Patient Information)
GenMeds checked this article against these documents on October 27, 2026. Your pharmacy’s package insert is always the final word for the medication you were dispensed.